How can I slow down the progression of my age-related macular degeneration?

Answer: Ask your doctor about trying supplements of zinc and antioxidant vitamins (beta-carotene, Vitamin C and vitamin E).

“The review of trials found that supplementation with antioxidants and zinc may be of modest benefit in people with AMD. Long-term harm from these supplements cannot be ruled out.”
Cochrane Database Syst Rev. 2006 Apr 19;(2):CD000254.
Evans JR.

Plain language summary


Antioxidant vitamins and mineral supplements to slow down the progression of age-related macular degeneration

Age-related macular degeneration (AMD) is a condition affecting the central area of the retina (back of the eye). The retina can deteriorate with age and some people get lesions that can lead to loss of central vision. It has been suggested that progression of the disease may be slowed down in people who eat a diet rich in antioxidant vitamins (carotenoids, vitamins C and E) or minerals (selenium and zinc). The author identified nine randomised controlled trials; four trials based in the USA, four in Australia, Austria, Switzerland and the UK and one in China. The review of trials found that supplementation with antioxidants and zinc may be of modest benefit in people with AMD. Long-term harm from these supplements cannot be ruled out. Large well-conducted trials in a range of populations and with different nutritional status are required.

Here is the scientific abstract:

Abstract

Background

It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals that are produced in the process of light absorption.

Objectives

The objective of this review was to assess the effects of antioxidant vitamin or mineral supplementation on the progression of age-related macular degeneration (AMD).

Search strategy

We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2007, Issue 3); MEDLINE (1966 to August 2007); EMBASE (1980 to August 2007); NRR (2007, Issue 3); AMED (1985 to January 2006); PubMed (24 January 2006 covering last 60 days) and SIGLE (1980 to March 2005), reference lists of identified reports and the Science Citation Index. We contacted investigators and experts in the field for details of unpublished studies.

Selection criteria

We included randomised trials comparing antioxidant vitamin or mineral supplementation (alone or in combination) to a control intervention in people with AMD.

Data collection and analysis

The author extracted data and assessed trial quality. Where appropriate, data were pooled using a random-effects model unless three or fewer trials were available in which case a fixed-effects model was used.

Main results

Nine trials were included in this review. The majority of people were randomised in one trial (AREDS in the USA) that found a beneficial effect of antioxidant (beta-carotene, vitamin C and vitamin E) and zinc supplementation on progression to advanced AMD (adjusted odds ratio 0.68, 99% confidence interval 0.49 to 0.93). People taking supplements were less likely to lose 15 or more letters of visual acuity (adjusted odds ratio 0.77, 99% confidence interval 0.58 to 1.03). Hospitalisation for genito-urinary problems was more common in people taking zinc and yellowing of skin was more common in people taking antioxidants. The other trials were, in general, small and the results were inconsistent.

Authors’ conclusions

The evidence as to the effectiveness of antioxidant vitamin and mineral supplementation in halting the progression of AMD comes mainly from one large trial in the USA. The generalisability of these findings to other populations with different nutritional status is not known. Further large, well-conducted randomised controlled trials in other populations are required. Long-term harm from supplementation cannot be ruled out. Beta-carotene has been found to increase the risk of lung cancer in smokers; vitamin E has been associated with an increased risk of heart failure in people with vascular disease or diabetes.

I have Type 2 diabetes. How can I gain better control over my blood sugar?

Answer: Exercise!

“This review found that exercise improves blood sugar control and that this effect is evident even without weight loss. . .Exercise improved the body’s reaction to insulin and decreased blood lipids. . .No adverse effects with exercise were reported.”

Cochrane Database Syst Rev. 2006 Jul 19;3:CD002968.

Exercise for type 2 diabetes mellitus.

Plain language summary


Exercise, dietary changes and medications are frequently used in the management of type 2 diabetes. However, it is difficult to determine the independent effect of exercise from some trials because exercise has been combined with dietary modifications or medications, or compared with a control which includes another form of intervention. The review authors aimed to determine the effect of exercise on blood sugar control in type 2 diabetes.

This review found that exercise improves blood sugar control and that this effect is evident even without weight loss. Furthermore, exercise decreases body fat content, thus the failure to lose weight with exercise programmes is probably explained by the conversion of fat to muscle. Exercise improved the body’s reaction to insulin and decreased blood lipids. Quality of life was only assessed in one study, which found no difference between the two groups. No significant difference was found between groups in blood levels of cholesterol or blood pressure. A total of 14 randomised controlled trials were assessed. These included 377 participants and compared groups that differed only with respect to an exercise programme intervention. The duration of the interventions in the studies ranged from eight weeks to one year. Two studies reported follow-up information, one at six months after the end of the six month exercise intervention and one at twelve months post-intervention. Generally, the studies were well-conducted, but blinding of outcome assessors was not reported and although all studies reported that randomisation was performed, few gave details of the method.

No adverse effects with exercise were reported. The effect of exercise on diabetic complications was not assessed in any of the studies.

The relatively short duration of trials prevented the reporting of any significant long term complications or mortality. Another limitation was the small number of participants included in the analyses for adiposity, blood pressure, cholesterol, body’s muscle and quality of life.

Now I am older, what can I do to reduce my chances of falling?

Answer:  Exercise!  All exercise that improves your balance, flexibility, strength and endurance will help. Tai Chi looks good.


Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007146.

Interventions for preventing falls in older people living in the community.

Plain language summary


Interventions for preventing falls in older people living in the community
As people get older, they may fall more often for a variety of reasons including problems with balance, poor vision, and dementia. Up to 30% may fall per year. Although one in five falls may require medical attention, less than one in 10 results in a fracture. Fear of falling can result in self-restricted activity levels. It may not be possible to prevent falls completely, but people who tend to fall frequently may be enabled to fall less often.

This review looked at which methods are effective for older people living in the community, and includes 111 randomised controlled trials, with a total of 55,303 participants.

Exercise programmes may target strength, balance, flexibility, or endurance. Programmes that contain two or more of these components reduce rate of falls and number of people falling. Exercising in supervised groups, participating in Tai Chi, and carrying out individually prescribed exercise programmes at home are all effective.

Multifactorial interventions assess an individual person’s risk of falling, and then carry out or arrange referral for treatment to reduce their risk. They have been shown in some studies to be effective, but have been ineffective in others. Overall current evidence shows that they do reduce rate of falls in older people living in the community. These are complex interventions, and their effectiveness may be dependent on factors yet to be determined.

Taking vitamin D supplements probably does not reduce falls, except in people who have a low level of vitamin D in the blood. These supplements may be associated with high levels of calcium in the blood, gastrointestinal discomfort, and kidney disorders.

Interventions to improve home safety do not seem to be effective, except in people at high risk, for example with severe visual impairment. An anti-slip shoe device worn in icy conditions can reduce falls.

Some medications increase the risk of falling. Ensuring that medications are reviewed and adjusted may be effective in reducing falls. Gradual withdrawal from some types of drugs for improving sleep, reducing anxiety and treating depression has been shown to reduce falls.

Cataract surgery reduces falls in people having the operation on the first affected eye. Insertion of a pacemaker can reduce falls in people with frequent falls associated with carotid sinus hypersensitivity, a condition which may result in changes in heart rate and blood pressure.

Another review of the scientific literature concludes that multi-component exercise is the most effective answer:

The most effective physical therapy approach for the prevention of falls and fractures in community-dwelling older adults is regular multicomponent exercise; a combination of balance and strength training has shown the most success.

Nature Reviews Endocrinology 6, 396-407 (July 2010) | doi:10.1038/nrendo.2010.70

Physical therapy approaches to reduce fall and fracture risk among older adults

Saija Karinkanta, Maarit Piirtola, Harri Sievänen, Kirsti Uusi-Rasi & Pekka Kannus

Abstract

Falls and fall-related injuries, such as fractures, are a growing problem among older adults, often causing longstanding pain, functional impairments, reduced quality of life and excess health-care costs and mortality. These problems have led to a variety of single component or multicomponent intervention strategies to prevent falls and subsequent injuries. The most effective physical therapy approach for the prevention of falls and fractures in community-dwelling older adults is regular multicomponent exercise; a combination of balance and strength training has shown the most success. Home-hazard assessment and modification, as well as assistive devices, such as canes and walkers, might be useful for older people at a high risk of falls. Hip protectors are effective in nursing home residents and potentially among other high-risk individuals. In addition, use of anti-slip shoe devices in icy conditions seems beneficial for older people walking outdoors. To be effective, multifactorial preventive programs should include an exercise component accompanied by individually tailored measures focused on high-risk populations. In this Review, we focus on evidence-based physical therapy approaches, including exercise, vibration training and improvements of safety at home and during periods of mobility. Additionally, the benefits of multifaceted interventions, which include risk factor assessment, dietary supplements, elements of physical therapy and exercise, are addressed.